Galera : Late-stage Trial Of Avasopasem On Severe Oral Mucositis Fails To Meet Main Goal; Stock Down
Galera Therapeutics Inc. (GRTX) said that phase 3 ROMAN trial of avasopasem did not meet its primary endpoint of reduction in the incidence of severe oral mucositis.
In Tuesday pre-market trade, GRTX was trading at $2.00, down $5.40 or 72.973%.
The trial demonstrated relative reduction in all key severe oral mucositis endpoints, including more than halving the median duration. Avasopasem was generally well tolerated with similar rates of adverse events in the active and placebo arms, the company said in a statement.
The trial evaluated avasopasem manganese (avasopasem) for severe oral mucositis in patients with locally advanced head and neck cancer undergoing standard-of-care radiotherapy.
The ROMAN trial is a randomized, double-blind, placebo-controlled trial in 455 patients with locally advanced HNC receiving seven weeks of standard-of-care radiotherapy plus cisplatin. Patients were randomized to one of the two treatment groups (3:2) to receive 90 mg of avasopasem or placebo by infusion on the days they receive their radiation treatment.
Oral mucositis is a side effect of radiation therapy characterized by severe pain, inflammation, ulceration and bleeding of the mouth. In patients with head and neck cancer, radiotherapy is a mainstay of treatment.
The company said it remains committed to its goal of transforming radiotherapy in cancer treatment with its selective dismutase mimetics.
Leo Terrell: If McAuliffe loses Virginia election, Democrats are in trouble in midterms
Leo Terrell: If Democrats lose VA election, they will lose the midterms in 2022
Fox News contributor Leo Terrell discusses how a Terry McAuliffe loss in Virginia could cost the Democrats the state in 2022
Fox News contributor Leo Terrell said Tuesday that if Democrat Terry McAuliffe loses the Virginia gubernatorial election to Republican Glenn Youngkin, then the Democrats will lose the midterms in 2022.
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LEO TERRELL: Well I’ll tell you right now, look Biden won Virginia by 10 points. McAuliffe is in a dogfight. Also, there are Black Republicans who are voting for Youngkin. There are Black Democrats voting for Youngkin. So the Democrats are pulling out all stops; Stacey Abrams, Barack Obama. They are in trouble. If they lose Virginia you can tell the Democratic Party that they’re gonna lose the midterms in 2022.
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Why did Couric conceal some of Justice Ginsburg's comments?
New York (CNN Business)Katie Couric says she has “no relationship” with Matt Lauer, her former ‘Today’ co-anchor who was fired in 2017 for inappropriate sexual behavior.
She spoke out on her former show Tuesday to promote the release of her new memoir, “Going There.” In an interview with current ‘Today’ host Savannah Guthrie, Couric said the scandal took her a “long time to process” because she didn’t know that side of Lauer.
“As I got more information and learned what was going on behind the scenes, it was really upsetting and disturbing,” she said, adding that it was “really devastating, but also disgusting.”
Couric admitted in the “Today” interview that there was a side of Lauer that she “never really knew,” and she tried to understand why he was so “abusive to other women.” The book also contains text messages between Couric and Lauer that showed how their relationship “devolved and ultimately deteriorated.”
“We have no relationship,” Couric stated. She and Lauer anchored the NBC morning show together for nearly a decade before she left in 2006 to host “CBS Evening News.”
In 2017, Lauer said he was “truly sorry” for the pain he has caused. Last year, he denied a rape allegation brought to light by author Ronan Farrow. Lauer could not immediately be reached for comment.
Couric’s book is being released October 26.
ManpowerGroup Q3 Profit Soars; Guides Q4 EPS – Quick Facts
While reporting financial results for the third quarter on Tuesday, workforce solutions provider ManpowerGroup, Inc. (MAN) said it expects earnings for the fourth quarter to be in the range of $1.99 to $2.07, which includes an estimated unfavorable currency impact of $0.04.
The guidance also includes an estimated impact from the ettain group acquisition of $0.13, but excludes acquisition transaction and integration costs.
For the third quarter, the company reported net earnings of $97.7 million or $1.80 per share, sharply higher than $10.3 million or $0.18 per share in the prior-year quarter.
Excluding the restructuring charges and acquisition costs, adjusted earnings for the quarter were $1.93 per share.
Revenues for the quarter grew 12.1 percent to $5.14 billion from $4.58 billion in the same quarter last year. Revenues were up 11 percent in constant currency.
Homebuilding slows as materials shortages linger
Supply shortages to be ‘major problem’ for housing if not fixed soon: NAHB CEO
National Association of Home Builders CEO Jerry Howard on consumer sentiment and how supply issues are impacting builders in the housing industry.
Homebuilding slowed in September as the ongoing materials shortage continued to drive up construction costs.
Housing starts fell 1.6% last month to a seasonally adjusted annualized rate of 1.555 million, the Commerce Department said Tuesday. Analysts surveyed by Refinitiv were expecting 1.62 million starts.
Permits for future construction plunged 7.7% to 1.589 million, missing the 1.68 million that was anticipated.
Supply chain disruptions that have occurred in the wake of the pandemic have left builders scrambling to find materials. The shortages have resulted in higher costs, causing many builders to delay projects.
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Despite the shortages, the National Association of Home Builders said in a report released Monday that builder confidence unexpectedly rose four points in October to a three-month high of 80. Any reading above 80 signals strong demand.
"Policymakers must focus on fixing the broken supply chain," said NAHB chief economist Robert Dietz. "This will spur more construction and help ease upward pressure on home prices."