INOVIO Pharma Announces Positive Results From Phase 1b Clinical Trial Evaluating INO-4201
Biotechnology company INOVIO Pharmaceuticals, Inc. (INO) announced Thursday positive results from a Phase 1b clinical trial evaluating INO-4201, a DNA vaccine candidate, as a booster in healthy adult participants who previously received a single injection of Ervebo.
In the trial, INO-4201 was well-tolerated and boosted humoral responses in 100% (36 of 36) of treated participants.
INO-4201 was evaluated in a 46-participant randomized, placebo-controlled Phase 1b trial (NCT04906629) to assess its safety, tolerability, and immunogenicity in healthy adult participants who previously received a single injection of Ervebo, a vaccine approved by the U.S. Food and Drug Administration for the prevention of disease caused by Zaire ebolavirus in individuals 18 years of age and older.
The participants were dosed with 1 mg of INO-4201 injected intradermally followed by electroporation using our investigational proprietary smart device, CELLECTRA. The trial was designed to test whether INO-4201 can be used as a booster in healthy participants previously vaccinated with Ervebo.
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Illinois Tool Works Q4 Profit Surges; Beats Estimates; Projects 3-5% Growth For FY23
Illinois Tool Works Inc. (ITW) Thursday announced a surge in fourth-quarter earnings compared to the prior year. Revenues were up 10 percent. Further, the company provided earnings outlook for the full year 2023 and expects organic growth of 3-5 percent.
The fourth quarter earnings were $907 million, up from $609 million last year. On a per-share basis, earnings were $2.95 compared to $1.93 a year ago. On an adjusted basis, earnings were $2.34 per share.
On average, 19 analysts polled by Thomson Reuters expected the company to earn $2.58 per share. Analysts estimates usually exclude special items.
Revenue for the quarter increased to $3.971 billion from $3.679 billion last year. Wall Street was looking for $3.89 billion.
Looking ahead to the full year 2023, the company provided earnings guidance in a range of $9.40-$9.80 per share. On an organic basis, growth is projected to increased by 3-5 percent.
Analysts project earnings of $9.33 per share in a range of $8.84-$10.75 per share.
Properly Tied Recalls Children's Lounge Pants
Properly Tied recalls about 1,960 children’s lounge pants due to violation of federal flammability standards and risk of burn.
According to the Consumer Product Safety Commission, the recalled children’s sleepwear fails to meet the federal flammability standards for children’s sleepwear, posing a risk of burn injuries to children.
The recall involves Properly Tied children’s lounge pants made of 100% cotton. The lounge pants were advertised as “LD Aspen Loungepant.” The lounge pants were available in sizes 2T through YXL and sold in the following print patterns: blaze, blue ridge, clay mountain and forest.
The company has asked customers to immediately take the recalled children’s sleepwear away from children, stop using them and contact Properly Tied for instructions on how to receive a pre-paid mailer to return the lounge pants for a full refund.
The products were sold at Sweet Threads, Britches and Bows, May May’s, The Carousel, Bundle of Joy, Dragonflies, Tugboat and the Bird, Lora Belle Baby, Peach Tree Kids, Hannah B’s and children’s product stores nationwide and online at www.properlytied.com from July 2020 through August 2022 for between $19 and $38.
Grainger Targets Daily Sales Growth Of 7%-11% For 2023
Grainger (GWW) said, for 2023, the company expects: earnings per share in a range of $32.00 – $34.50; and net sales of $16.2 – $16.8 billion. Sales growth is estimated to be 6.6% – 10.6%, and daily sales growth is expected in a range of 7.0% – 11.0%.
Fourth quarter adjusted earnings per share were $7.14, up 31.3% versus the fourth quarter of 2021. The company said the increase in earnings per share was due primarily to the strong operating performance in the quarter. Analysts on average had expected the company to earn $7.01 per share, according to figures compiled by Thomson Reuters. Analysts’ estimates typically exclude special items. Earnings per share were $7.54 on a reported basis, up 38.6% versus the fourth quarter of 2021.
Fourth quarter sales were $3.8 billion, increased 13.2%, or 17.2% on a daily, constant currency basis versus the fourth quarter of 2021.
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Rogers Communications Q4 Net Rises Helped By Revenue Growth
Canada-based communications and media company Rogers Communications Inc. (RCI) on Thursday reported higher revenues and earnings for the fourth quarter.
On February 1, the Board declared a dividend of C$0.50 per Class A Share and Class B Non-Voting Share to be paid on April 3, to shareholders of record on March 10.
Net income stood at C$508 million or C$1.00 per share as compared to C$405 million or C$0.80 per share in the prior period.
Adjusted net income stood at C$554 million or C$1.09 per share as compared to C$486 million or C$0.96 per share in the prior-period quarter.
Net income increased by 25% and adjusted net income increased by 14% primarily as a result of higher adjusted EBITDA, partially offset by higher income taxes and higher finance costs attributable to the Shaw acquisition-related senior note financing.
Total revenue increased 6 percent to C$4.17 billion, from C$3.9 billion in the prior period.
The company also issued 2023 guidance envisaging a Total service revenue growth range of 4% to 7% and an adjusted EBITDA growth range of 5% to 8%. Capital expenditures excluding Shaw is estimated between C$3.1 billion and C$3.3 billion compared to C$3.03 billion in 2022.
Shares of Rogers Communications Inc. closed Wednesday’s trading at $48.68, up $0.03 or 0.06 percent from the previous close.