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By Bret Stephens
FDA Approves AbbVie’s RINVOQ To Treat Active Psoriatic Arthritis
AbbVie (ABBV) said that the U.S. Food and Drug Administration has approved RINVOQ (upadacitinib; 15 mg, once daily) for the treatment of adults with active psoriatic arthritis who have had an inadequate response or intolerance to one or more tumor necrosis factor blockers.
The FDA approval is supported by data from two phase 3 clinical studies where RINVOQ (15 mg, once daily) showed efficacy across multiple measures of disease activity in active psoriatic arthritis with a safety profile consistent with that seen in rheumatoid arthritis.
The company noted that RINVOQ helps to improve joint pain, swelling and stiffness, as well as fatigue, and prevent further joint damage for patients with active Psoriatic arthritis.
The milestone marks the second FDA-approved indication for RINVOQ following rheumatoid arthritis in 2019.
Psoriatic arthritis is a heterogeneous, systemic inflammatory disease with hallmark manifestations across multiple domains including joints and skin. In Psoriatic arthritis, the immune system causes inflammation that can lead to skin lesions associated with psoriasis, pain, fatigue and stiffness in the joints. Psoriatic arthritis affects about 30% of people with psoriasis.
Fire breaks out at Hong Kong's World Trade center, injuring one
- Firefighters were battling the blaze with two water jets, the government said, with breathing apparatus deployed and ladders used to rescue people inside the building.
- Police said about 100 people moved from a restaurant to a podium on the 39th floor when the fire broke out and smoke filled the dining area, according to local broadcaster RTHK.
One person was injured after a fire broke out at Hong Kong's World Trade Centre in the bustling commercial and shopping district of Causeway Bay, the government said on Wednesday, with media reporting dozens of people trapped inside.
The blaze was upgraded to a level 3 incident on a scale of one to five.
Firefighters were battling the blaze with two water jets, the government said, with breathing apparatus deployed and ladders used to rescue people inside the building.
Police said about 100 people moved from a restaurant to a podium on the 39th floor when the fire broke out and smoke filled the dining area, according to local broadcaster RTHK.
The scene outside the World Trade Centre was calm after firefighters cordoned off the area.
In 2005, an iPod was sold every two seconds. See how CNN covered the phenomenon
(CNN Business)Apple will once again require anyone inside its US retail stores to wear a mask as concerns mount over rising Covid-19 cases and the spread of the Omicron variant.
“Amid rising cases in many communities, we now require that all customers join our team members in wearing masks while visiting our stores,” Apple spokesperson Nick Leahy said in a statement Tuesday.
The iPhone maker had gradually relaxed mask requirements in some cities and regions over time, based on local regulations. Masks were mandatory at about half its stores prior to this week’s policy change, Leahy said.
Apple has changed its store policies several times over the past two years in response to developments in the spread of Covid-19, such as closing, reopening and re-closing stores on multiple occasions. The company has served as something of a bellwether for the broader retail industry’s response to the pandemic. Other US businesses including Walmart (WMT), Starbucks (SBUX) and McDonald’s (MCD) also reinstated their mask mandates earlier this year in response to the spread of the Delta variant.
Some US states such as California and New York have also temporarily reinstated mask mandates indoors, with New York providing an exemption for businesses that require proof of vaccination.
UK inflation jumps to 10-year high as petrol prices soar
Increase to 5.1% in November puts further pressure on Bank of England to raise interest rates
Last modified on Wed 15 Dec 2021 02.37 EST
UK inflation jumped to 5.1% in November as the price of petrol reached a record high and a computer chip shortage continued to push up the cost of cars.
The Office for National Statistics (ONS) said the increase took the consumer prices annual rate to its highest level since September 2011, when it stood at 5.2%.
Analysts said the increase in that measure from 4.2% in October is expected to put further pressure on the Bank of England to raise interest rates when it meets on Thursday, although the spread of the Omicron variant may deter policymakers from taking such action until the new year.
Petrol was one of the main drivers of inflation after it rose to an average 145.8p a litre in November compared with 112.6p a litre a year earlier. The November 2021 price is the highest recorded.
Used car prices increased by 3.1% from October to November 2021, leading to a cumulative increase of 31.3% since April 2021, the ONS said.
The other parts of the inflation basket of goods and services to increase in price were food and non-alcoholic beverages, clothing and footwear, and furniture and household goods, the ONS added.